I am in chronic pain every day. I take celadrin and do get some benefit from it. What I have found most beneficial from Celadrin is not what you would expect. It has helped reduce my cholesterol. I went from having constant high cholesterol numbers for my entire life ( aged 50 now) where at one point it reached as high as 525 when the doctors put me on statins. I had to stop taking the statins due to nose bleeds and muscle soreness. Since I have been using Celadrin my cholesterol has dropped from 325 to 211. This is unheard for me.