by | Feb 23, 2002 | Nationalnutrition.ca

Helping to reduce joint inflammation …

Cetylated (pronounced “set-ill-eighted”) fatty acids are naturally occurring fats such as cetyl myristoleate, cetyl laureate, and cetyl palmitate. These nutrients have come into the spotlight in recent years for their potential ability to reduce the symptoms of osteoarthritis (OA), and some autoimmune conditions such as: rheumatoid arthritis (RA), Sjogren’s syndrome, lupus, and multiple sclerosis (MS).

Interest in examining the health benefits of cetylated fatty acids began early in the new millennium. Because of this, there isn’t a lot of research, and most of the studies are quite small (less than 50 participants). This gives us a good preliminary idea of the potential applications of these substances, but not the complete picture.
There is not enough evidence as of yet for the use of cetylated fatty acids in autoimmune conditions, as research has not yet examined this area. At any rate, initial research suggests that cetylated fatty acids can be taken as an oral supplement or used topically in a cream to effectively treat osteoarthritis.

Cetylated fatty acids have been shown to reduce pain and increase functional performance in OA sufferers. The functional performance tested included: strength, range of motion, ability to climb stairs, and the ability to walk immediately after standing. In general there was a 10-15% improvement with the use of either oral or topical cetylated fatty acids in each of these areas. Benefits were shown to be more dramatic when the use of cetylated fatty acids was combined with physical therapy.

How do they work?
Because the research on cetylated fatty acids is so new, the mechanism of action is not yet understood. It is theorized that they help to lubricate joints and muscles, soften tissues, and may potentially help to reduce improper immune responses. More research is required for us to be sure of how they work.

Celadrin is a proprietary formula produced by a company called Live the Source (LTS). This supplement consists of cetylated fatty acids in a proprietary “esterified fatty acid complex (EFAC)”. This particular formula has a few limited studies supporting its use in OA that are very similar to those conducted on cetylated fatty acids in general.

How can I use cetylated fatty acids?
Cetylated fatty acids can be taken orally in a capsule form or can be found in topical creams that can be applied to affected areas. Most of the dosing information of cetylated fatty acids comes from research performed on the proprietary blend called Celadrin, thus recommendations will be made for this substance. Celadrin can be taken at a dose of 350mg, up to six times daily. Topical mixtures can be applied to the affected joints twice daily to promote the relief of osteoarthritis. It is likely that these dosages apply to all cetylated fatty acids, but further research is required.

Important Information
Because of the limited research on cetylated fatty acids, there is very little information on side effects or interactions. At this time there are no known side effects or interactions. It may be wise to avoid oral supplementation during pregnancy or breast-feeding until further research establishes safety at these times.

Nutritional Information

Sources· Naturally Occurring.
Applications· Osteoarthritis Potential Applications For Rheumatoid Arthritis, And Some Autoimmune Conditions, But Further Research Is Required
Optimum Dosage· Take 350mg Of Celadrin Up To 6 Times Daily. Use Topical Creams Up To 2x Daily. (Clinical Doses May Differ As Recommended By Your Healthcare Practitioner).
Important Information· Long Term Safety Is Not Known.
· Avoid Supplementing Orally During Pregnancy Or Breast-Feeding Until Further Research Establishes Safety.
For Informational Purposes Only. Please Consult Your Health Care Practitioner Before Taking Natural Health Care Products.

Originally posted for Nationalnutrition.ca: https://www.nationalnutrition.ca/articles/supplements/celadrin/

Lorna Vanderhaeghe, MSC
Lorna Vanderhaeghe, MSC

A health journalist, Vanderhaeghe as been researching and writing on the subject of nutritional medicine for over 20 years. She is past editor in chief of Healthy Living Guide and Alive magazine. Lorna is the author of A Smart Woman’s Guide to Hormones, A Smart Woman’s Guide to Weight Loss, A Smart Woman’s Guide to Heart Health, the A-Z Woman’s Guide to Vibrant Health and many more.


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